1198098-03-1

1198098-03-1 structure

Name: (5Z)-2-amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one
Chemical Name: 5-(3,4-Dimethoxy-benzylidene)-2-imino-thiazolidin-4-one
CAS Number: 1198098-03-1
Molecular Formula: C₁₂H₁₂N₂O₃S
Molecular Weight: 264.300
Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
Create Date: 2018-06-05 00:36:13
Modify Date: 2024-04-09 10:48:08
GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease[1].

Name	5-(3,4-Dimethoxy-benzylidene)-2-imino-thiazolidin-4-one
Synonyms	4(5H)-Thiazolone, 2-amino-5-[(3,4-dimethoxyphenyl)methylene]-, (5Z)- 5-(3,4-Dimethoxy-benzylidene)-2-imino-thiazolidin-4-one (5Z)-2-Amino-5-(3,4-dimethoxybenzylidene)-1,3-thiazol-4(5H)-one

Description	GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3β:80.5 nM (IC50)
References	[1]. Arfeen M, et al. Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3β inhibitors. Eur J Med Chem. 2016 Oct 4;121:727-736.