Diptoindonesin G
Modify Date: 2025-10-01 22:41:21
Diptoindonesin G structure
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Common Name | Diptoindonesin G | ||
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| CAS Number | 1190948-58-3 | Molecular Weight | 360.321 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H12O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Diptoindonesin GA natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ. |
| Name | Diptoindonesin G |
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| Description | A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ. |
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| References | References 1. Zhao Z, et al. Chem Biol. 2015 Dec 17;22(12):1608-21. 2. Juliawaty LD, et al. Nat Prod Commun. 2009 Jul; 4(7):947-50. 3. Gao J, et al. Cell Death Dis. 2017 May 4;8(5):e2765. View Related Products by Target Estrogen Receptor/ERR |
| Molecular Formula | C21H12O6 |
|---|---|
| Molecular Weight | 360.321 |
| InChIKey | BYHAUTWYDTUGRC-UHFFFAOYSA-N |
| SMILES | O=C1c2c(O)cc(O)cc2-c2c(-c3ccc(O)cc3)oc3cc(O)cc1c23 |