Diptoindonesin G

A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ.

References 1. Zhao Z, et al. Chem Biol. 2015 Dec 17;22(12):1608-21. 2. Juliawaty LD, et al. Nat Prod Commun. 2009 Jul; 4(7):947-50. 3. Gao J, et al. Cell Death Dis. 2017 May 4;8(5):e2765. View Related Products by Target Estrogen Receptor/ERR