Mitoxantrone-d8

Modify Date: 2024-01-10 17:14:57

Mitoxantrone-d8 Structure
Mitoxantrone-d8 structure
Common Name Mitoxantrone-d8
CAS Number 1189974-82-0 Molecular Weight 452.53000
Density N/A Boiling Point N/A
Molecular Formula C22H20D8N4O6 Melting Point 145 °C
MSDS N/A Flash Point N/A

 Use of Mitoxantrone-d8


Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].

 Names

Name Mitoxantrone-d8
Synonym More Synonyms

 Mitoxantrone-d8 Biological Activity

Description Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7.

[3]. Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.

[4]. Vibet S, et al. Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. Drug Metab Dispos. 2007 May;35(5):822-8.

[5]. Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8(2):157-62.

 Chemical & Physical Properties

Melting Point 145 °C
Molecular Formula C22H20D8N4O6
Molecular Weight 452.53000
Exact Mass 452.25100
PSA 163.18000
LogP 0.78860

 Safety Information

Hazard Codes Xi

 Synonyms

1,4-dihydroxy-5,8-bis[2-[(1,1,2,2-tetradeuterio-2-hydroxyethyl)amino]ethylamino]anthracene-9,10-dione