TIK-301 structure
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Common Name | TIK-301 | ||
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CAS Number | 118702-11-7 | Molecular Weight | 280.750 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 525.9±50.0 °C at 760 mmHg | |
Molecular Formula | C14H17ClN2O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 271.9±30.1 °C |
Use of TIK-301TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3]. |
Name | LY-156,735 |
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Synonym | More Synonyms |
Description | TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3]. |
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Related Catalog | |
Target |
melatonin MT1:0.081 nM (Ki) melatonin MT2:0.042 nM (Ki) 5-HT2C Receptor 5-HT2B Receptor |
In Vivo | In male rats, TIK-301(at doses of 0.8 and 4.0 mg/kg/day) can reduce body weight, and without altering food intake[1][2]. The Tmax and half-life of TIK-301 is 1.1 hour and 1 hour, respectively[1]. |
References |
[3]. Carocci A, et al. Melatonergic drugs in development. Clin Pharmacol. 2014 Sep 18;6:127-37. |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 525.9±50.0 °C at 760 mmHg |
Molecular Formula | C14H17ClN2O2 |
Molecular Weight | 280.750 |
Flash Point | 271.9±30.1 °C |
Exact Mass | 280.097870 |
LogP | 1.86 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.596 |
N-[(2R)-2-(6-Chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide |
Acetamide, N-[(2R)-2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl]- |
LY-156,735 |
PD-6735 |
3ZX95B1ZWK |
TIK-301 |