TIK-301

Modify Date: 2024-01-02 17:14:13

TIK-301 structure	Common Name	TIK-301
	CAS Number	118702-11-7	Molecular Weight	280.750
	Density	1.2±0.1 g/cm3	Boiling Point	525.9±50.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₇ClN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	271.9±30.1 °C

Use of TIK-301

TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3].

Name	LY-156,735
Synonym	More Synonyms

Description	TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	melatonin MT1:0.081 nM (Ki) melatonin MT2:0.042 nM (Ki) 5-HT2C Receptor 5-HT2B Receptor
In Vivo	In male rats, TIK-301(at doses of 0.8 and 4.0 mg/kg/day) can reduce body weight, and without altering food intake[1][2]. The Tmax and half-life of TIK-301 is 1.1 hour and 1 hour, respectively[1].
References	[1]. Paulis L, et al. Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs. 2012 Nov;21(11):1661-78. [2]. Rivara S, et al. Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8(11):954-68. [3]. Carocci A, et al. Melatonergic drugs in development. Clin Pharmacol. 2014 Sep 18;6:127-37.

Density	1.2±0.1 g/cm3
Boiling Point	525.9±50.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₇ClN₂O₂
Molecular Weight	280.750
Flash Point	271.9±30.1 °C
Exact Mass	280.097870
LogP	1.86
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.596

N-[(2R)-2-(6-Chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide

Acetamide, N-[(2R)-2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl]-

LY-156,735

PD-6735

3ZX95B1ZWK

TIK-301

TIK-301

Use of TIK-301

Names

TIK-301 Biological Activity

Chemical & Physical Properties

Synonyms