DPPE fumarate

Modify Date: 2024-01-12 19:21:24

DPPE fumarate structure	Common Name	DPPE fumarate
	CAS Number	1185241-83-1	Molecular Weight	399.480
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₉NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DPPE fumarate

Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].

Name	2-(4-Benzylphenoxy)-N,N-diethylethanamine (2E)-2-butenedioate (1:1)
Synonym	More Synonyms

Description	Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Tesmilifene may modulate the effects of 12(S)HETE in cancer cells, and indirectly, influence the susceptibility of cellular DNA to chemotherapy[1].
In Vivo	Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2]. Animal Model: Male BKTO mice (25-45 g)[2]. Dosage: 20 mg/kg (s.c.) and 20 μg (icv in 5 μL). Administration: S.C. and icv. Result: Potentiated seizures induced by both convulsants.
References	[1]. Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66(4):715-31. [2]. G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9.

Molecular Formula	C₂₃H₂₉NO₅
Molecular Weight	399.480
Exact Mass	399.204559

2-(4-Benzylphenoxy)-N,N-diethylethanamine (2E)-but-2-enedioate (1:1)

2-(4-Benzylphenoxy)-N,N-diethylethanamine (2E)-2-butenedioate (1:1)

Ethanamine, N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-, (2E)-2-butenedioate (1:1)

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DPPEfumarate
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Tesmilifene fumarate
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DPPE FUMARATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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