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DPPE fumarate

Names

[ CAS No. ]:
1185241-83-1

[ Name ]:
DPPE fumarate

[Synonym ]:
2-(4-Benzylphenoxy)-N,N-diethylethanamine (2E)-but-2-enedioate (1:1)
2-(4-Benzylphenoxy)-N,N-diethylethanamine (2E)-2-butenedioate (1:1)
Ethanamine, N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-, (2E)-2-butenedioate (1:1)

Biological Activity

[Description]:

Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[In Vitro]

Tesmilifene may modulate the effects of 12(S)HETE in cancer cells, and indirectly, influence the susceptibility of cellular DNA to chemotherapy[1].

[In Vivo]

Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2]. Animal Model: Male BKTO mice (25-45 g)[2]. Dosage: 20 mg/kg (s.c.) and 20 μg (icv in 5 μL). Administration: S.C. and icv. Result: Potentiated seizures induced by both convulsants.

[References]

[1]. Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66(4):715-31.

[2]. G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H29NO5

[ Molecular Weight ]:
399.480

[ Exact Mass ]:
399.204559

Related Compounds