(D-Arg2,Lys4)-Dermorphin (1-4) amide structure
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Common Name | (D-Arg2,Lys4)-Dermorphin (1-4) amide | ||
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CAS Number | 118476-85-0 | Molecular Weight | 611.73600 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C30H45N9O5 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of (D-Arg2,Lys4)-Dermorphin (1-4) amideDALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects[1]. |
Name | 6-amino-2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]hexanamide |
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Synonym | More Synonyms |
Description | DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects[1]. |
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Related Catalog | |
Target |
μ Opioid Receptor/MOR:1.69 nM (Ki) κ Opioid Receptor/KOR:4230 nM (Ki) δ Opioid Receptor/DOR:19200 nM (Ki) |
In Vitro | DALDA 在生理 pH 值下携带净正电荷 (3+),因此是亲水的,比吗啡更极性[1]。 |
In Vivo | DALDA (0-7 nmol/rat; i.t.; once) 在大鼠中表现出抗痛和呼吸作用[1]。 DALDA (0.1 and 1.0 μg/side; ICV; once) 在大鼠中产生双相效应,初始抑制,中间显著抑制,接着是水平运动、饲养和刻板印象次数的激活[2]。 Animal Model: Male Sprague-Dawley rats (300–350 g)[1] Dosage: 0.24, 0.7 and 7 nmol/rat Administration: Intrathecal injection, once Result: Showed antinociceptive effects with an ED50 of 237 pmol/rat in the rat tail-flick test. Inhibited the uptake of NE in spinal cord synaptosomes in a dose-dependent manner. Had no effect on 5-HT uptake. Produced depression in minute ventilation. Animal Model: Male Long-Evans rats, weighing 200-225 g[2] Dosage: 0, 0.1 and 1.0 μg/side, 0.5 μL Administration: Lateral cerebral ventricle injection, once Result: Elicited a significant biphasic effect with an initial suppression, an intermediate marked inhibition, followed by significant activation for horizontal movement time, rearing time, and stereotypy time. |
References |
Molecular Formula | C30H45N9O5 |
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Molecular Weight | 611.73600 |
Exact Mass | 611.35400 |
PSA | 264.56000 |
LogP | 3.30120 |
Risk Phrases | 20-35-52/53 |
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Safety Phrases | 26-36/37/39-45-61 |
RIDADR | UN 1759 8/PG 2 |
[D-Arg2 (Lys4]-Dermorphin-(1-4)-amide |
H-Tyr-D-Arg-Phe-Lys-NH2 |
DALDA |
(D-Arg2,Lys4)-Dermorphin (1-4) amide |