TG 4-155
Modify Date: 2024-01-03 17:26:03
TG 4-155 structure
|
Common Name | TG 4-155 | ||
|---|---|---|---|---|
| CAS Number | 1164462-05-8 | Molecular Weight | 394.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H26N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of TG 4-155TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a Ki of 9.9 nM[1][2]. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1[1]. TG4-155 has an EP2 Schild KB of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor[2]. |
| Name | (E)- N-(2-(2-methyl-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide |
|---|---|
| Synonym | More Synonyms |
| Description | TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a Ki of 9.9 nM[1][2]. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1[1]. TG4-155 has an EP2 Schild KB of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor[2]. |
|---|---|
| Related Catalog | |
| Target |
EP2 Receptor:9.9 nM (Ki) |
| References |
[2]. Ganesh T. Prostanoid receptor EP2 as a therapeutic target. J Med Chem. 2014 Jun 12;57(11):4454-65. |
| Molecular Formula | C23H26N2O4 |
|---|---|
| Molecular Weight | 394.46 |
| Exact Mass | 394.18900 |
| PSA | 61.72000 |
| LogP | 4.19600 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P280-P305 + P351 + P338-P337 + P313 |
| RIDADR | NONH for all modes of transport |
| TG4-155 |
| (E)-N-(2-(2-methyl-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide |
| N-(2-(2-methyl-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide |