LFF-571
Modify Date: 2024-04-02 20:24:40
LFF-571 structure
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Common Name | LFF-571 | ||
|---|---|---|---|---|
| CAS Number | 1160959-55-6 | Molecular Weight | 1366.61 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C60H63N13O13S6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LFF-571LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL.LFF571 demonstrated activity against most other Gram-positive rods and cocci (MIC50/90, 0.125/0.25 μg/mL) except for bifidobacteria and some species of lactobacilli, showed reduced active activity against Gram-negative anaerobes with MICs for Bacteroides fragilis of 4 and 8 μg/mL.LFF571 inhibits exogenous protein synthesis elongation factor EF-Tu and interferes with the ability for EF-Tu to deliver aminoacylated tRNA to the ribosome. |
| Name | LFF-571 |
|---|
| Description | LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL.LFF571 demonstrated activity against most other Gram-positive rods and cocci (MIC50/90, 0.125/0.25 μg/mL) except for bifidobacteria and some species of lactobacilli, showed reduced active activity against Gram-negative anaerobes with MICs for Bacteroides fragilis of 4 and 8 μg/mL.LFF571 inhibits exogenous protein synthesis elongation factor EF-Tu and interferes with the ability for EF-Tu to deliver aminoacylated tRNA to the ribosome. |
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| References | 1. LaMarche MJ, et al. J Med Chem. 2012 Mar 8;55(5):2376-87. 2. Trzasko A, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4459-62. 3. Leeds JA, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4463-5. |
| Molecular Formula | C60H63N13O13S6 |
|---|---|
| Molecular Weight | 1366.61 |
| InChIKey | GNLYKLDXQZHYTR-QWSGWXDSSA-N |
| SMILES | CNC(=O)CC1NC(=O)c2csc(n2)-c2ccc(-c3nc(N(CCCCC(=O)O)C(=O)OC4CCC(C(=O)O)CC4)cs3)nc2-c2csc(n2)-c2csc(n2)C(C(O)c2ccccc2)NC(=O)CNC(=O)c2nc(sc2COC)C(C(C)C)NC(=O)c2nc1sc2C |