UNII:76LB1G2X6V

Modify Date: 2024-01-08 08:17:39

UNII:76LB1G2X6V structure	Common Name	UNII:76LB1G2X6V
	CAS Number	115104-28-4	Molecular Weight	515.09
	Density	1.3±0.1 g/cm3	Boiling Point	712.3±60.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₂₇ClN₂O₃S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	384.6±32.9 °C

Use of UNII:76LB1G2X6V

MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release[1][2][3].

Name	MK 571,3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoicacid
Synonym	More Synonyms

Description	MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Inflammation/Immunology
Target	LTD4:0.22 nM (Ki, In guinea pig lung) LTD4:2.1 nM (Ki, In human lung) LTD4:10.5 (pA2, on guinea pig ileum) LTE4:10.4 (pA2, on guinea pig ileum)
References	[1]. Jones TR, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D₄ receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28. [2]. Hara Y, et al. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest. 2011 Jul;121(7):2888-97. [3]. Mitra P, et al. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9.

Density	1.3±0.1 g/cm3
Boiling Point	712.3±60.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₇ClN₂O₃S₂
Molecular Weight	515.09
Flash Point	384.6±32.9 °C
Exact Mass	514.115173
PSA	121.10000
LogP	5.93
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.687
Storage condition	20°C

Hazard Codes	Xn
Risk Phrases	36/37/38
Safety Phrases	26-36/37

Precursor 9
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CAS#:115104-47-7 methyl 3-(((3-(...
DownStream 0