1160959-55-6
1160959-55-6 structure
- Name: LFF-571
- Chemical Name: LFF-571
- CAS Number: 1160959-55-6
- Molecular Formula: C60H63N13O13S6
- Molecular Weight: 1366.61
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-08-07 01:27:05
- Modify Date: 2024-04-02 20:24:40
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LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL.LFF571 demonstrated activity against most other Gram-positive rods and cocci (MIC50/90, 0.125/0.25 μg/mL) except for bifidobacteria and some species of lactobacilli, showed reduced active activity against Gram-negative anaerobes with MICs for Bacteroides fragilis of 4 and 8 μg/mL.LFF571 inhibits exogenous protein synthesis elongation factor EF-Tu and interferes with the ability for EF-Tu to deliver aminoacylated tRNA to the ribosome.
| Name | LFF-571 |
|---|
| Description | LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL.LFF571 demonstrated activity against most other Gram-positive rods and cocci (MIC50/90, 0.125/0.25 μg/mL) except for bifidobacteria and some species of lactobacilli, showed reduced active activity against Gram-negative anaerobes with MICs for Bacteroides fragilis of 4 and 8 μg/mL.LFF571 inhibits exogenous protein synthesis elongation factor EF-Tu and interferes with the ability for EF-Tu to deliver aminoacylated tRNA to the ribosome. |
|---|---|
| References | 1. LaMarche MJ, et al. J Med Chem. 2012 Mar 8;55(5):2376-87. 2. Trzasko A, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4459-62. 3. Leeds JA, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4463-5. |
| Molecular Formula | C60H63N13O13S6 |
|---|---|
| Molecular Weight | 1366.61 |