Fascaplysin (chloride)|CDK4 inhibitor

Modify Date: 2024-01-02 17:03:02

Fascaplysin (chloride)\|CDK4 inhibitor structure	Common Name	Fascaplysin (chloride)\|CDK4 inhibitor
	CAS Number	114719-57-2	Molecular Weight	306.75
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₁ClN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Fascaplysin (chloride)|CDK4 inhibitor

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].

Name	Fascaplysin
Synonym	More Synonyms

Description	Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)[2]. Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity[2]. .Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells[2].
In Vivo	Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2]
References	[1]. BenjaminPelcman, Gordon WGribble. Total synthesis of the marine sponge pigment fascaplysin. Tetrahedron Letters. 1990, 31(17):2381-2384. [2]. Zhidkov ME, et al. Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues. Mar Drugs. 2019 Aug 25;17(9):496.

Molecular Formula	C₁₈H₁₁ClN₂O
Molecular Weight	306.75
Exact Mass	306.05600
PSA	36.74000
LogP	0.14620

Fascaplysin (chloride)|CDK4 inhibitor MSDS(Chinese)

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26

Precursor 7
CAS#:132911-52-5 homofascaplysin C CAS#:22980-09-2 indole-3-glyoxy... CAS#:496-15-1 Indoline CAS#:65610-76-6 1-(1,2-Dioxo-2-...
CAS#:120-72-9 Indole CAS#:73540-77-9 N-(methoxymethy... CAS#:146336-96-1 (Z)-ethyl 3-(1-...
DownStream 0