Fascaplysin (chloride)|CDK4 inhibitor
Names
[ CAS No. ]:
114719-57-2
[ Name ]:
Fascaplysin (chloride)|CDK4 inhibitor
[Synonym ]:
fascaplysine
GNF-PF-1458
Biological Activity
[Description]:
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].
[Related Catalog]:
[In Vitro]
Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)[2]. Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity[2]. .Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells[2].
[In Vivo]
Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C18H11ClN2O
[ Molecular Weight ]:
306.75
[ Exact Mass ]:
306.05600
[ PSA ]:
36.74000
[ LogP ]:
0.14620
MSDS
Safety Information
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26