Indoline
Names
[ CAS No. ]:
496-15-1
[ Name ]:
Indoline
[Synonym ]:
2,3-dihydro-1H-1-indole
Indoline
IDN
trans-dihydroindole
2,3-dihydro-1H-indole
EINECS 207-816-8
MFCD00005705
2,3-DIHYDROINDOLE
1H-Indole, 2,3-dihydro-
1-Azaindan
2,3-Dihydro-1H-indol
dihydroindole
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
227.2±10.0 °C at 760 mmHg
[ Melting Point ]:
-21 °C
[ Molecular Formula ]:
C8H9N
[ Molecular Weight ]:
119.164
[ Flash Point ]:
92.8±0.0 °C
[ Exact Mass ]:
119.073502
[ PSA ]:
12.03000
[ LogP ]:
1.63
[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.562
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
5 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NL6906300
- CHEMICAL NAME :
- 1H-Indole, 2,3-dihydro-
- CAS REGISTRY NUMBER :
- 496-15-1
- BEILSTEIN REFERENCE NO. :
- 0111915
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C8-H9-N
- MOLECULAR WEIGHT :
- 119.18
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >238 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1620,1974
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S23-S24/25-S37/39-S26
[ WGK Germany ]:
3
[ RTECS ]:
NL6906300
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Chem. Commun. (Camb.) 49(31) , 3254-6, (2013)
Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration...
FeCl3-mediated Friedel-Crafts hydroarylation with electrophilic N-acetyl indoles for the synthesis of benzofuroindolines.Angew. Chem. Int. Ed. Engl. 51(50) , 12546-50, (2012)
IRONic electrophilic indoles! The C3-regioselective hydroarylation of N-acetyl indoles with aromatic nucleophiles mediated by FeCl(3) features a rare example of the electrophilic reactivity of the ind...
Identification and Testing of Novel CARP-1 Functional Mimetic Compounds as Inhibitors of Non-Small Cell Lung and Triple Negative Breast Cancers.J. Biomed. Nanotechnol. 11 , 1608-27, (2015)
The triple negative breast cancer (TNBCs) and non-small cell lung cancers (NSCLCs) often acquire mutations that contribute to failure of drugs in clinic and poor prognosis, thus presenting an urgent n...