Chemical Communications 2013-04-21

Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines.

Ping-Xin Zhou, Jian-Yi Luo, Lian-Biao Zhao, Yu-Ying Ye, Yong-Min Liang

Index: Chem. Commun. (Camb.) 49(31) , 3254-6, (2013)

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Abstract

Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration of a wide range of functional groups, (2) easy to handle and with mild conditions, (3) enriches the isoindoline family, (4) two new bonds form in one step.

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