2-(2-Aminophenyl)ethanol

Names

[ Name ]:
2-(2-Aminophenyl)ethanol

[Synonym ]:
Phenethyl alcohol, o-amino-
2-Aminophenethyl alcohol
(β-Hydroxyethyl)aniline
MFCD00007754
2-(2-Aminophenyl)ethyl Alcohol
Benzeneethanol, 2-amino-
EINECS 226-275-9
2-(2-Aminophenyl)ethanol
2-(o-aminophenyl)ethanol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
306.7±0.0 °C at 760 mmHg

[ Melting Point ]:
89ºC

[ Molecular Formula ]:
C₈H₁₁NO

[ Molecular Weight ]:
137.179

[ Flash Point ]:
127.9±20.4 °C

[ Exact Mass ]:
137.084061

[ PSA ]:
46.25000

[ LogP ]:
0.08

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.597

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Ruthenium-catalyzed dehydrogenative N-heterocyclization. Indoles from 2-aminophenethyl alcohols and 2-nitrophenethyl alcohols. Tsuji Y, et al.

J. Org. Chem. 55(2) , 580-84, (1990)

N-(Cyanothioformyl) indoline; a new indoline ring forming reaction. Besson T, et al.

J. Chem. Soc. Perkin Trans. I 24 , 4057-60, (1998)

One-pot cyclization of 2-aminophenethyl alcohols: a novel and direct approach to the synthesis of N-acyl indolines.

J. Org. Chem. 72(24) , 9364-7, (2007)

A unique one-pot cyclization of 2-aminophenethyl alcohols with carboxylic acids in the presence of PPh3, CCl4, and NEt3 furnished the formation of N-acyl indolines in good to excellent yields. This ne...