GSK-3β inhibitor 8
Modify Date: 2024-01-18 01:55:57
GSK-3β inhibitor 8 structure
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Common Name | GSK-3β inhibitor 8 | ||
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| CAS Number | 1139875-74-3 | Molecular Weight | 413.924 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 632.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C20H20ClN5OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 336.2±34.3 °C | |
Use of GSK-3β inhibitor 8GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2]. |
| Name | GSK3β Inhibitor XVIII |
|---|---|
| Synonym | More Synonyms |
| Description | GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2]. |
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| Related Catalog | |
| Target |
GSK-3β:64 nM (IC50) |
| In Vitro | GSK-3β inhibitor 8 (化合物 1a) (1 nM-100 μM; 7 d) 剂量依赖性地刺激 β 细胞增殖，EC50 值为 1.41 μM。GSK-3β inhibitor 8 (2 μM; 72 h) 使复制 R7T1 β 细胞增加约 2 倍[1]。 GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) 诱导 Super (8X) TOPFlash 报告晶活化，EC50 值为 1.25 μM[1]。 GSK-3β inhibitor 8 (2 μM; 72 h) 刺激 HEK293 细胞 β-catenin 转位进入细胞核[1]。 |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 632.3±65.0 °C at 760 mmHg |
| Molecular Formula | C20H20ClN5OS |
| Molecular Weight | 413.924 |
| Flash Point | 336.2±34.3 °C |
| Exact Mass | 413.107697 |
| LogP | 3.59 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.666 |
| GSK3β Inhibitor XVIII |
| (2-Chloro-4-{[4-(2-thienyl)-2-pyrimidinyl]amino}phenyl)(4-methyl-1-piperazinyl)methanone |
| Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)- |