1139875-74-3

1139875-74-3 structure

Name: GSK-3β inhibitor 8
Chemical Name: GSK3Î² Inhibitor XVIII
CAS Number: 1139875-74-3
Molecular Formula: C₂₀H₂₀ClN₅OS
Molecular Weight: 413.924
Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
Create Date: 2022-03-23 20:27:54
Modify Date: 2024-01-18 01:55:57
GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2].

Name	GSK3Î² Inhibitor XVIII
Synonyms	GSK3Î² Inhibitor XVIII (2-Chloro-4-{[4-(2-thienyl)-2-pyrimidinyl]amino}phenyl)(4-methyl-1-piperazinyl)methanone Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-

Description	GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Inflammation/Immunology Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3β:64 nM (IC50)
In Vitro	GSK-3β inhibitor 8 (化合物 1a) (1 nM-100 μM; 7 d) 剂量依赖性地刺激 β 细胞增殖，EC50 值为 1.41 μM。GSK-3β inhibitor 8 (2 μM; 72 h) 使复制 R7T1 β 细胞增加约 2 倍[1]。 GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) 诱导 Super (8X) TOPFlash 报告晶活化，EC50 值为 1.25 μM[1]。 GSK-3β inhibitor 8 (2 μM; 72 h) 刺激 HEK293 细胞 β-catenin 转位进入细胞核[1]。
References	[1]. Wang W, et al. Identification of small-molecule inducers of pancreatic beta-cell expansion. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32.