CGP 78608 hydrochloride
Modify Date: 2025-08-26 17:00:52
CGP 78608 hydrochloride structure
|
Common Name | CGP 78608 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1135278-54-4 | Molecular Weight | 414.58 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H14BrClN3O5P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CGP 78608 hydrochlorideCGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity[1][2]. |
| Name | CGP 78608 hydrochloride |
|---|
| Description | CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites[2]. CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity[3]. |
| In Vivo | CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice[1]. |
| References |
[1]. Catarzi D, et al. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21. |
| Molecular Formula | C11H14BrClN3O5P |
|---|---|
| Molecular Weight | 414.58 |
| InChIKey | MZQQZBPMRPDKTB-JEDNCBNOSA-N |
| SMILES | CC(NCc1cc(Br)cc2[nH]c(=O)c(=O)[nH]c12)P(=O)(O)O.Cl |