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123690-79-9

123690-79-9 structure
123690-79-9 structure
  • Name: CGP 35348
  • Chemical Name: 3-aminopropyl(diethoxymethyl)phosphinic acid
  • CAS Number: 123690-79-9
  • Molecular Formula: C8H20NO4P
  • Molecular Weight: 225.22
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
  • Create Date: 2018-11-25 12:17:06
  • Modify Date: 2025-08-25 21:06:32
  • CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].
Name 3-aminopropyl(diethoxymethyl)phosphinic acid
Synonyms Acridine Orange hydrochloride
Tocris-1245
C8H20NO4P
(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate
MFCD00882736
Description CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].
Related Catalog
In Vivo CGP 35348 enhances non-REM sleep and rapid eye movement (REM) sleep and reduces strongly spike-wave discharges. Both behavioural and electroencephalogram (EEG) parameters contributed to the establishment of a hypnotic effect. The highest dose of CGP 35348 was not effective in promoting REM sleep. The REM-sleep-enhancing effects might have theoretical and clinical relevance. Animal Model: Eight male Wistar rats[3] Dosage: 100, 300, and 900 mg/kg  Administration: Intraperitoneally given Result: Produced an increase in the duration of REM sleep compared to the saline-injected control group at 100 and 300 mg/kg.
References

[1]. H R Olpe,et al. CGP 35348: a centrally active blocker of GABAB receptors. CGP 35348: a centrally active blocker of GABAB receptors

[2]. Q Gillani, et al. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215.

[3]. A Puigcerver, et al.  Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats. Brain Res Bull. 1996;40(3):157-62.

Density 1.131g/cm3
Boiling Point 400.5ºC at 760mmHg
Molecular Formula C8H20NO4P
Molecular Weight 225.22
Flash Point 196ºC
Exact Mass 225.11300
PSA 91.59000
LogP 1.66250
Vapour Pressure 1.55E-07mmHg at 25°C
Index of Refraction 1.459
Storage condition 20°C
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title: CAS No. 123690-79-9 | Chemsrc address: https://www.chemsrc.com/en/baike/671822.html

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