Biotin-PEG5-amine

Modify Date: 2025-08-24 18:56:40

Biotin-PEG5-amine Structure
Biotin-PEG5-amine structure
Common Name Biotin-PEG5-amine
CAS Number 113072-75-6 Molecular Weight 506.656
Density 1.2±0.1 g/cm3 Boiling Point 744.2±60.0 °C at 760 mmHg
Molecular Formula C22H42N4O7S Melting Point N/A
MSDS N/A Flash Point 403.9±32.9 °C

 Use of Biotin-PEG5-amine


Biotin-PEG5-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name N-(17-Amino-3,6,9,12,15-pentaoxaheptadec-1-yl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Synonym More Synonyms

 Biotin-PEG5-amine Biological Activity

Description Biotin-PEG5-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 744.2±60.0 °C at 760 mmHg
Molecular Formula C22H42N4O7S
Molecular Weight 506.656
Flash Point 403.9±32.9 °C
Exact Mass 506.277405
LogP -2.50
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.510

 Synonyms

1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(17-amino-3,6,9,12,15-pentaoxaheptadec-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)-
N-(17-Amino-3,6,9,12,15-pentaoxaheptadec-1-yl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
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