NF 110
Modify Date: 2025-08-27 12:58:51
NF 110 structure
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Common Name | NF 110 | ||
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| CAS Number | 111150-22-2 | Molecular Weight | 1096.91000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H28N6Na4O17S4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NF 110NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons[1]. |
| Name | NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt |
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| Synonym | More Synonyms |
| Description | NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons[1]. |
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| Related Catalog | |
| Target |
Ki: 36 nM (P2X3 Receptor) |
| In Vitro | NF110 shows an activity in the human tumour cell line panel, with IC30 of 362.3 μM[2]. NF110 inhibits HMGA2-DNA interactions with an IC50 of 0.87 μM[3]. |
| In Vivo | NF110 shows potency at Endogenous P2X Receptors in Rat DRG Neurons, with a peak amplitude of 675 pA[1]. |
| References |
| Molecular Formula | C41H28N6Na4O17S4 |
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| Molecular Weight | 1096.91000 |
| Exact Mass | 1096.00000 |
| PSA | 419.85000 |
| LogP | 8.71740 |
| nf110 |