NF 1819

Modify Date: 2025-08-30 10:55:52

NF 1819 Structure
NF 1819 structure
 Common Name NF 1819
CAS Number 1881244-28-5 Molecular Weight 463.46
Density 1.5±0.1 g/cm3 Boiling Point 660.5±65.0 °C at 760 mmHg
Molecular Formula C24H22FN5O4 Melting Point N/A
MSDS N/A Flash Point 353.2±34.3 °C

 Use of NF 1819


MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant[1].

 Names

Name (3R,4S)-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H-1,2,4-triazol-1-ylcarbonyl)-4-piperidinyl]-2-azetidinone
Synonym More Synonyms

 NF 1819 Biological Activity

Description MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant[1].
Related Catalog
References

[1]. Brindisi M, et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016 Mar 24;59(6):2612-32.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 660.5±65.0 °C at 760 mmHg
Molecular Formula C24H22FN5O4
Molecular Weight 463.46
Flash Point 353.2±34.3 °C
Exact Mass 463.165588
LogP 1.14
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.735

 Synonyms

MFCD31544489
(3R,4S)-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H-1,2,4-triazol-1-ylcarbonyl)-4-piperidinyl]-2-azetidinone
2-Azetidinone, 4-(1,3-benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H-1,2,4-triazol-1-ylcarbonyl)-4-piperidinyl]-, (3R,4S)-
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Chemsrc provides NF 1819(CAS#:1881244-28-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of NF 1819 are included as well.>> amp version: NF 1819

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