NF 1819

Names

[ Name ]:
NF 1819

[Synonym ]:
MFCD31544489
(3R,4S)-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H-1,2,4-triazol-1-ylcarbonyl)-4-piperidinyl]-2-azetidinone
2-Azetidinone, 4-(1,3-benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H-1,2,4-triazol-1-ylcarbonyl)-4-piperidinyl]-, (3R,4S)-

Biological Activity

[Description]:

MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL

Research Areas >> Inflammation/Immunology

[References]

[1]. Brindisi M, et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016 Mar 24;59(6):2612-32.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
660.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₂FN₅O₄

[ Molecular Weight ]:
463.46

[ Flash Point ]:
353.2±34.3 °C

[ Exact Mass ]:
463.165588

[ LogP ]:
1.14

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.735

Related Compounds

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