1227098-15-8
1227098-15-8 structure
- Name: NF-κB-IN-1
- Chemical Name: NF-κB-IN-1
- CAS Number: 1227098-15-8
- Molecular Formula: C31H30O8
- Molecular Weight: 530.57
- Catalog: Signaling Pathways NF-κB IKK
- Create Date: 2021-09-11 15:07:31
- Modify Date: 2025-08-25 13:48:55
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NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells[1].
| Name | NF-κB-IN-1 |
|---|
| Description | NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells[1]. |
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| Related Catalog | |
| Target |
IKK[1] |
| In Vitro | NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI50s of 0.72, 0.07, 0.13, and 0.16 μM, respectively[1]. NF-κB-IN-1 (0.5-25 μM; pretreated for 30 min or 4 h) potently blocks the IκB phosphorylation and degradation in A549 cells[1]. NF-κB-IN-1 (0.1-100 μM; pretreated for 30 min) dose-dependently inhibits the TNFα-induced nuclear translocation of NF-κB in A549 cells, with an IC50s of 1.0 μM[1]. NF-κB-IN-1 (0.1-0.4 μM; 9 d) inhibits lung cancer clonogenic activity[1]. Cell Viability Assay[1] Cell Line: A549, H1944, H460 and H157 cells Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 72 hours Result: Decreased viability of lung adenocarcinoma cells A549 and H1944, quamous cell carcinoma cells H157, and large cell carcinoma cells H460 in a dose-dependent manner. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 0.5, 1.0, 2.5, 5.0, 10.0, 25.0 μM Incubation Time: Pretreated for 30 min or 4 h Result: Blocked IκB phosphorylation, with an IC50 of 2.8 μM. Blocked IκB degradation in a dose-dependent manner. |
| References |
| Molecular Formula | C31H30O8 |
|---|---|
| Molecular Weight | 530.57 |
| Hazard Codes | Xi |
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