SCD1-IN-1
Modify Date: 2025-10-26 11:32:06
SCD1-IN-1 structure
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Common Name | SCD1-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1111078-63-7 | Molecular Weight | 395.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H20F3NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SCD1-IN-1SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition[1]. |
| Name | SCD1-IN-1 |
|---|
| Description | SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition[1]. |
|---|---|
| Related Catalog | |
| Target |
SCD1[1]. |
| In Vitro | SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC50 value of 6.8 nM[1]. |
| In Vivo | SCD1-IN-1 (compound I, 1.5% w/v, 25 μL, applied to surfaces of ears) reduces in cholesterol ester (CE) and wax ester (WE) production in hamster ear model[1]. Animal Model: Hamster ear model[1] Dosage: 1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL. Administration: Applied to ~3 cm2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks. Result: Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size. |
| References |
[1]. Li Jin, et al. Phenoxy-pyrrolidine derivative and its use and compositions Patent. WO2009019566. |
| Molecular Formula | C20H20F3NO4 |
|---|---|
| Molecular Weight | 395.37 |
| InChIKey | MZYNHNDFHWNIIU-INIZCTEOSA-N |
| SMILES | O=C(COc1ccc(CO)cc1)N1CCC(Oc2ccccc2C(F)(F)F)C1 |