Ruthenium red

Modify Date: 2024-01-02 14:55:32

Ruthenium red Structure
Ruthenium red structure
Common Name Ruthenium red
CAS Number 11103-72-3 Molecular Weight 786.354
Density 3.11 Boiling Point N/A
Molecular Formula Cl6H42N14O2Ru3 Melting Point >500ºC
MSDS Chinese USA Flash Point N/A

 Use of Ruthenium red


Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker[1][2].

 Names

Name Ruthenium Red
Synonym More Synonyms

 Ruthenium red Biological Activity

Description Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker[1][2].
Related Catalog
Target

ICa[2]

In Vitro Ruthenium red staining of intracellular organelles and structures seemed to depend on the time of exposure to this agent, as well on the concentration used[2]. Ruthenium red efficiently blocks the L-type calcium current in a dose-dependent manner in in guinea-pig isolated ventricular heart cells, with EC50 of 0.8 μM[2]. Ruthenium red (10 μM) blocks the sarcoplasmic Ca release channels or the mitochondrial Ca uptake, and blocks 26.7 % of the sodium current, and slowed its inactivation time-course in guinea-pig isolated ventricular heart cells[2].
References

[1]. Lashanda N Waller, et al. Ruthenium red staining for ultrastructural visualization of a glycoprotein layer surrounding the spore of Bacillus anthracis and Bacillus subtilis. J Microbiol Methods. 2004 Jul;58(1):23-30.

[2]. Claire O Malécot, et al. Ruthenium red as an effective blocker of calcium and sodium currents in guinea-pig isolated ventricular heart cells. Br J Pharmacol. 1998 Jun; 124(3): 465–472.

 Chemical & Physical Properties

Density 3.11
Melting Point >500ºC
Molecular Formula Cl6H42N14O2Ru3
Molecular Weight 786.354
Exact Mass 785.887817
PSA 63.82000

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 28439000

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 Synonyms

MFCD00011479
Ruthenium red
Ammoniated ruthenium oxychloride
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