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11103-72-3

11103-72-3 structure
11103-72-3 structure
  • Name: Ruthenium red
  • Chemical Name: Ruthenium Red
  • CAS Number: 11103-72-3
  • Molecular Formula: Cl6H42N14O2Ru3
  • Molecular Weight: 786.354
  • Catalog: Organic raw materials Organometallic compound Organic
  • Create Date: 2018-03-30 08:00:00
  • Modify Date: 2024-01-02 14:55:32
  • Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker[1][2].
Name Ruthenium Red
Synonyms MFCD00011479
Ruthenium red
Ammoniated ruthenium oxychloride
Description Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker[1][2].
Related Catalog
Target

ICa[2]
In Vitro Ruthenium red staining of intracellular organelles and structures seemed to depend on the time of exposure to this agent, as well on the concentration used[2]. Ruthenium red efficiently blocks the L-type calcium current in a dose-dependent manner in in guinea-pig isolated ventricular heart cells, with EC50 of 0.8 μM[2]. Ruthenium red (10 μM) blocks the sarcoplasmic Ca release channels or the mitochondrial Ca uptake, and blocks 26.7 % of the sodium current, and slowed its inactivation time-course in guinea-pig isolated ventricular heart cells[2].
References

[1]. Lashanda N Waller, et al. Ruthenium red staining for ultrastructural visualization of a glycoprotein layer surrounding the spore of Bacillus anthracis and Bacillus subtilis. J Microbiol Methods. 2004 Jul;58(1):23-30.

[2]. Claire O Malécot, et al. Ruthenium red as an effective blocker of calcium and sodium currents in guinea-pig isolated ventricular heart cells. Br J Pharmacol. 1998 Jun; 124(3): 465–472.
Density 3.11
Melting Point >500ºC
Molecular Formula Cl6H42N14O2Ru3
Molecular Weight 786.354
Exact Mass 785.887817
PSA 63.82000
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 28439000

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title: CAS No. 11103-72-3 | Chemsrc address: https://www.chemsrc.com/en/baike/587371.html

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