MCOPPB trihydrochloride

Modify Date: 2025-08-26 22:52:43

MCOPPB trihydrochloride structure	Common Name	MCOPPB trihydrochloride
	CAS Number	1108147-88-1	Molecular Weight	518.005
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₄₃Cl₃N₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MCOPPB trihydrochloride

MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors.IC50 value: 10.07 (pKi)Target: nociceptin receptorMCOPPB trihydrochloride is a trihydrochloride form of MCOPPB that is a new nonpeptide nociceptin/orphanin FQ peptide (NOP)-receptor agonist with a pKi of 10.07 ± 0.01 for the human NOP receptor.

Name	MCOPPB (hydrochloride)
Synonym	More Synonyms

Description	MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors.IC50 value: 10.07 (pKi)Target: nociceptin receptorMCOPPB trihydrochloride is a trihydrochloride form of MCOPPB that is a new nonpeptide nociceptin/orphanin FQ peptide (NOP)-receptor agonist with a pKi of 10.07 ± 0.01 for the human NOP receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Others
References	[1]. Hayashi, Shigeo; Hirao, Akiko; Imai, Aki; Nakamura, Hiroshi; Murata, Yoshinori; Ohashi, Katsuyo; Nakata, Eriko. Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure-Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug. Journal of Medicinal Chemistry (2009), 52(3), 610-625. [2]. Hayashi S, Hirao A, Imai A, Nakamura H, Murata Y, Ohashi K, Nakata E.Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug.J Med Chem. 2009 Feb 12;52(3):610-25. [3]. Hirao A, Imai A, Sugie Y, Yamada Y, Hayashi S, Toide K.Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent.J Pharmacol Sci. 2008 Mar;106(3):361-8. Epub 2008 Mar 5.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Others

References

[1]. Hayashi, Shigeo; Hirao, Akiko; Imai, Aki; Nakamura, Hiroshi; Murata, Yoshinori; Ohashi, Katsuyo; Nakata, Eriko. Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure-Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug. Journal of Medicinal Chemistry (2009), 52(3), 610-625.

[2]. Hayashi S, Hirao A, Imai A, Nakamura H, Murata Y, Ohashi K, Nakata E.Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug.J Med Chem. 2009 Feb 12;52(3):610-25.

[3]. Hirao A, Imai A, Sugie Y, Yamada Y, Hayashi S, Toide K.Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent.J Pharmacol Sci. 2008 Mar;106(3):361-8. Epub 2008 Mar 5.

Molecular Formula	C₂₆H₄₃Cl₃N₄
Molecular Weight	518.005
Exact Mass	516.255310
PSA	33.09000
LogP	8.31590
Storage condition	2-8℃

Urea,1-(1-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)azetidin-3-yl)-1-methyl

1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride

MCOPPB trihydrochloride

1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1Hbenzimidazole

1-(1-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YL)AZETIDIN-3-YL)-1-M ETHYLUREA

1H-Benzimidazole, 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-, hydrochloride (1:3)

Urea,N-[1-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-3-azetidinyl]-N-methyl

MCOPPB (triHydrochloride)

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MCOPPB trihydrochloride

Use of MCOPPB trihydrochloride

Names

MCOPPB trihydrochloride Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.