α-bungarotoxin

Modify Date: 2025-08-21 16:46:42

α-bungarotoxin Structure
α-bungarotoxin structure
Common Name α-bungarotoxin
CAS Number 11032-79-4 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula C338H528N97O105S11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of α-bungarotoxin


α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM[1][2].

 Names

Name α-Bungarotoxin

 α-bungarotoxin Biological Activity

Description α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM[1][2].
Related Catalog
In Vitro α-Bungarotoxin binds specifically and with high affinity to the nicotinic acetylcholine receptor and competes with binding of the natural ligand. α-Bungarotoxin (α-BTX), is a potent competitive inhibitors of nicotinic acetylcholine receptor function and is highly toxic due to functional blockade of AcChoRs at the neuromuscular junction[3].
References

[1]. Hannan S, et al. Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors. Neuropharmacology. 2015;93:28-40.

[2]. López MG, et al. Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc Natl Acad Sci U S A. 1998;95(24):14184-14189.

[3]. Balass M, et al. The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library. Proc Natl Acad Sci U S A. 1997;94(12):6054-6058.

 Chemical & Physical Properties

Molecular Formula C338H528N97O105S11
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