G 28UCM

Modify Date: 2024-01-05 08:54:24

G 28UCM structure	Common Name	G 28UCM
	CAS Number	1094451-90-7	Molecular Weight	464.378
	Density	1.7±0.1 g/cm3	Boiling Point	895.1±65.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₁₆O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	313.3±27.8 °C

Use of G 28UCM

UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines[1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli[2].

Name	1,3-Naphthalenediyl bis(3,4,5-trihydroxybenzoate)
Synonym	More Synonyms

Description	UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines[1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS) Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Teresa Puig, et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 2011;13(6):R131. [2]. Swayansiddha Tripathy, et al. FtsZ inhibitors as a new genera of antibacterial agents. Bioorg Chem. 2019 Oct;91:103169.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Teresa Puig, et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 2011;13(6):R131.

[2]. Swayansiddha Tripathy, et al. FtsZ inhibitors as a new genera of antibacterial agents. Bioorg Chem. 2019 Oct;91:103169.

Density	1.7±0.1 g/cm3
Boiling Point	895.1±65.0 °C at 760 mmHg
Molecular Formula	C₂₄H₁₆O₁₀
Molecular Weight	464.378
Flash Point	313.3±27.8 °C
Exact Mass	464.074341
LogP	4.63
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.787
Storage condition	-20°C

1,3-Naphthalenediyl bis(3,4,5-trihydroxybenzoate)

Benzoic acid, 3,4,5-trihydroxy-, 1,3-naphthalenediyl ester

DC Chemicals Limited
China
Product Name: UCM05
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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