1094451-90-7

1094451-90-7 structure

Name: G 28UCM
Chemical Name: 1,3-Naphthalenediyl bis(3,4,5-trihydroxybenzoate)
CAS Number: 1094451-90-7
Molecular Formula: C₂₄H₁₆O₁₀
Molecular Weight: 464.378
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-06-18 22:50:41
Modify Date: 2024-01-05 08:54:24
UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines[1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli[2].

Name	1,3-Naphthalenediyl bis(3,4,5-trihydroxybenzoate)
Synonyms	1,3-Naphthalenediyl bis(3,4,5-trihydroxybenzoate) Benzoic acid, 3,4,5-trihydroxy-, 1,3-naphthalenediyl ester

Description	UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines[1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS) Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Teresa Puig, et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 2011;13(6):R131. [2]. Swayansiddha Tripathy, et al. FtsZ inhibitors as a new genera of antibacterial agents. Bioorg Chem. 2019 Oct;91:103169.