ERK2 IN-1

Modify Date: 2024-01-10 00:36:36

ERK2 IN-1 structure	Common Name	ERK2 IN-1
	CAS Number	1093061-47-2	Molecular Weight	647.76
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₃₄FN₇O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ERK2 IN-1

ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM[1].

Name	ERK2 IN-1

Description	ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK2:7 nM (IC50)
In Vitro	ERK1/2 IN-1 (Compound 28) maintains good ERK enzymatic activity (ERK IC50=7 nM) and cellular activity in BRAF/KRAS mutant wildtype cancer cell lines (HT-29/Caspase IC50=118/80 nM)[1].
References	[1]. Boga SB, Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2029-2034.

Molecular Formula	C₃₆H₃₄FN₇O₂S
Molecular Weight	647.76