1093061-47-2

1093061-47-2 structure
1093061-47-2 structure
  • Name: ERK2 IN-1
  • Chemical Name: ERK2 IN-1
  • CAS Number: 1093061-47-2
  • Molecular Formula: C36H34FN7O2S
  • Molecular Weight: 647.76
  • Catalog: Signaling Pathways MAPK/ERK Pathway ERK
  • Create Date: 2019-06-01 18:45:25
  • Modify Date: 2024-01-10 00:36:36
  • ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM[1].

Name ERK2 IN-1
Description ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM[1].
Related Catalog
Target

ERK2:7 nM (IC50)

In Vitro ERK1/2 IN-1 (Compound 28) maintains good ERK enzymatic activity (ERK IC50=7 nM) and cellular activity in BRAF/KRAS mutant wildtype cancer cell lines (HT-29/Caspase IC50=118/80 nM)[1].
References

[1]. Boga SB, Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2029-2034.

Molecular Formula C36H34FN7O2S
Molecular Weight 647.76