ERK2 IN-1

Names

[ CAS No. ]:
1093061-47-2

[ Name ]:
ERK2 IN-1

Biological Activity

[Description]:

ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

ERK2:7 nM (IC50)

[In Vitro]

ERK1/2 IN-1 (Compound 28) maintains good ERK enzymatic activity (ERK IC50=7 nM) and cellular activity in BRAF/KRAS mutant wildtype cancer cell lines (HT-29/Caspase IC50=118/80 nM)[1].

[References]

[1]. Boga SB, Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2029-2034.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₃₄FN₇O₂S

[ Molecular Weight ]:
647.76

Related Compounds

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