ω-Conotoxin MVIIA
ω-Conotoxin MVIIA structure
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Common Name | ω-Conotoxin MVIIA | ||
|---|---|---|---|---|
| CAS Number | 107452-89-1 | Molecular Weight | 2639.134 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C102H172N36O32S7 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of ω-Conotoxin MVIIAZiconotide is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects[1]. |
| Name | Ziconotide acetate |
|---|---|
| Synonym | More Synonyms |
| Description | Ziconotide is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects[1]. |
|---|---|
| Target |
N-Type Ca2+ Channel |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C102H172N36O32S7 |
| Molecular Weight | 2639.134 |
| Exact Mass | 2637.098389 |
| PSA | 1310.94000 |
| LogP | -17.05 |
| Index of Refraction | 1.710 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H331 |
| Precautionary Statements | P261-P304 + P340 + P312-P403 + P233 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | T+ |
| RIDADR | UN 3172 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
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The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and [Ca2+]i in spinal cord synaptosomes.
Cell. Mol. Neurobiol. 31(2) , 277-83, (2011) In spinal cord synaptosomes, the spider toxin PhTx3-4 inhibited capsaicin-stimulated release of glutamate in both calcium-dependent and -independent manners. In contrast, the conus toxins, ω-conotoxin... |
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Rationale for Prospective Assays of Intrathecal Mixtures Including Morphine, Ropivacaine and Ziconotide: Prevention of Adverse Events and Feasibility in Clinical Practice.
Pain Physician 18 , 349-57, (2015) Use of intrathecal admixtures is widespread, but compounding these is sometimes challenging and may result in errors and complications causing super-potency or sub potency adverse events in patients o... |
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Prolonged delirium with psychotic features from omega conotoxin toxicity.
Pain Med. 14(3) , 447-8, (2013)
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| Ziconotide |
| ω-conotoxin MVIIA |
| SNX-111,Ziconotide |
| o-Conotoxin MVIIA |
| SNX-111 Ziconotide |
| snx111 |
| Ziconotideacetate |
| Prialt |
| SNX-111 |
| CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 |