ω-Conotoxin MVIIA

Names

[ Name ]:
ω-Conotoxin MVIIA

[Synonym ]:
Ziconotide
ω-conotoxin MVIIA
SNX-111,Ziconotide
o-Conotoxin MVIIA
SNX-111 Ziconotide
snx111
Ziconotideacetate
Prialt
SNX-111
CKGKGAKCSRLMYDCCTGSCRSGKC-NH2

Biological Activity

[Description]:

Ziconotide is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects[1].

[Target]

N-Type Ca2+ Channel

[References]

[1]. Brinzeu A, et al. Ziconotide for spinal cord injury-related pain. Eur J Pain. 2019 Oct;23(9):1688-1700.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₀₂H₁₇₂N₃₆O₃₂S₇

[ Molecular Weight ]:
2639.134

[ Exact Mass ]:
2637.098389

[ PSA ]:
1310.94000

[ LogP ]:
-17.05

[ Index of Refraction ]:
1.710

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H331

[ Precautionary Statements ]:
P261-P304 + P340 + P312-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T+

[ RIDADR ]:
UN 3172

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and [Ca2+]i in spinal cord synaptosomes.

Cell. Mol. Neurobiol. 31(2) , 277-83, (2011)

In spinal cord synaptosomes, the spider toxin PhTx3-4 inhibited capsaicin-stimulated release of glutamate in both calcium-dependent and -independent manners. In contrast, the conus toxins, ω-conotoxin...

Rationale for Prospective Assays of Intrathecal Mixtures Including Morphine, Ropivacaine and Ziconotide: Prevention of Adverse Events and Feasibility in Clinical Practice.

Pain Physician 18 , 349-57, (2015)

Use of intrathecal admixtures is widespread, but compounding these is sometimes challenging and may result in errors and complications causing super-potency or sub potency adverse events in patients o...

Prolonged delirium with psychotic features from omega conotoxin toxicity.

Pain Med. 14(3) , 447-8, (2013)

Related Compounds

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