Garcinone D

Modify Date: 2024-01-16 12:41:31

Garcinone D Structure
Garcinone D structure
Common Name Garcinone D
CAS Number 107390-08-9 Molecular Weight 428.475
Density 1.304 Boiling Point 674.2±55.0 °C at 760 mmHg
Molecular Formula C24H28O7 Melting Point 202-204 ºC
MSDS N/A Flash Point 231.2±25.0 °C

 Use of Garcinone D


Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners[1].

 Names

Name 1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methylbut-2-enyl)xanthen-9-one
Synonym More Synonyms

 Garcinone D Biological Activity

Description Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners[1].
Related Catalog
Target

p-STAT3

References

[1]. Yang X, et al. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 Jul 28;626:6-12.

 Chemical & Physical Properties

Density 1.304
Boiling Point 674.2±55.0 °C at 760 mmHg
Melting Point 202-204 ºC
Molecular Formula C24H28O7
Molecular Weight 428.475
Flash Point 231.2±25.0 °C
Exact Mass 428.183502
PSA 120.36000
LogP 3.71
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.625

 Safety Information

Hazard Codes Xi

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

1,3,6-Trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
Garcinone D
9H-Xanthen-9-one, 1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-butenyl)-
9H-Xanthen-9-one, 1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-buten-1-yl)-
1,3,6-Trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
9H-Xanthen-9-one,1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-butenyl)