Cevimeline

Modify Date: 2025-08-22 12:09:31

Cevimeline structure	Common Name	Cevimeline
	CAS Number	107233-08-9	Molecular Weight	199.31
	Density	1.2±0.1 g/cm3	Boiling Point	308.5±42.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₇NOS	Melting Point	195-197ºC
	MSDS	N/A	Flash Point	140.4±27.9 °C

Use of Cevimeline

Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.IC50 value:Target: M3 receptor

Name	cevimeline
Synonym	More Synonyms

Description	Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.IC50 value:Target: M3 receptor
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease
References	[1]. Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9. [2]. Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17. [3]. Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14. [4]. Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9. [5]. Tajiri S, et al. Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations.Int J Pharm. 2010 Jan 4;383(1-2):99-105. Epub 2009 Sep 10.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Neurological Disease

References

[1]. Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9.

[2]. Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17.

[3]. Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14.

[4]. Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9.

[5]. Tajiri S, et al. Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations.Int J Pharm. 2010 Jan 4;383(1-2):99-105. Epub 2009 Sep 10.

Density	1.2±0.1 g/cm3
Boiling Point	308.5±42.0 °C at 760 mmHg
Melting Point	195-197ºC
Molecular Formula	C₁₀H₁₇NOS
Molecular Weight	199.31
Flash Point	140.4±27.9 °C
PSA	37.77000
LogP	1.23
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.586
InChIKey	WUTYZMFRCNBCHQ-HTLJXXAVSA-N
SMILES	CC1OC2(CS1)CN1CCC2CC1
Storage condition	-20°C

3]oxathiolane]

CevimelineHClSalt

CEVIMELINE, HYDROCHLORIDE SALT

(2R,2'R)-2'-Methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane]

cis-2'-Methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane]

Evoxac

AF-102B

(2R,2'R)-2'-Methylspiro[4-azabicyclo[2.2.2]octan-2,5'-[1,3]oxathiolan]

(2R,2'R)-Cevimeline

Cevimeline

(2R,2'R)-rel-2'-Methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane]

3R)-rel

Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, (2'R,3R)-

SNI-2011

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Cevimeline

Use of Cevimeline

Names

Cevimeline Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.