BMY 14802 hydrochloride structure
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Common Name | BMY 14802 hydrochloride | ||
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CAS Number | 105565-55-7 | Molecular Weight | 384.85100 | |
Density | N/A | Boiling Point | 520.8ºC at 760mmHg | |
Molecular Formula | C18H23ClF2N4O | Melting Point | N/A | |
MSDS | N/A | Flash Point | 268.8ºC |
Use of BMY 14802 hydrochlorideBMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects[1][2][3]. |
Name | BMY 14802 hydrochloride,α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanolhydrochloride |
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Description | BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects[1][2][3]. |
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Related Catalog | |
Target |
5-HT1A Receptor α1-adrenergic receptor sigma Receptor:112 nM (IC50) |
In Vitro | Similar to other 5-HT1A agonists, BMY-14802 hydrochloride affects the firing of 5-HTergic and catecholaminergic neurons and affects behaviors mediated by 5-HT in a 5-HT1A-sensitive manner. BMY-14802 hydrochloride is devoid of significant affinity for the D2 receptor[3]. |
In Vivo | BMY-14802 (5 mg/kg, 10 mg/kg or 20 mg/kg, ip; once) hydrochloride shows anti-dyskinetic efficacy across a 4-fold dose range against L-DOPA-induced dyskinesias (LID) and is also effective in reducing D1 and D2 receptor agonist-induced dyskinesias. Importantly, at anti-LID doses, BMY-14802 hydrochloride does not affect the efficacy of L-DOPA against lesion-induced akinesia[2]. |
References |
Boiling Point | 520.8ºC at 760mmHg |
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Molecular Formula | C18H23ClF2N4O |
Molecular Weight | 384.85100 |
Flash Point | 268.8ºC |
Exact Mass | 384.15300 |
PSA | 52.49000 |
LogP | 3.19550 |
Vapour Pressure | 1.13E-11mmHg at 25°C |