5-Chloroindole-2-carboxylic acid

Modify Date: 2024-01-02 17:31:00

5-Chloroindole-2-carboxylic acid Structure
5-Chloroindole-2-carboxylic acid structure
Common Name 5-Chloroindole-2-carboxylic acid
CAS Number 10517-21-2 Molecular Weight 195.602
Density 1.5±0.1 g/cm3 Boiling Point 449.7±25.0 °C at 760 mmHg
Molecular Formula C9H6ClNO2 Melting Point 287 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 225.8±23.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 5-Chloroindole-2-carboxylic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 449.7±25.0 °C at 760 mmHg
Melting Point 287 °C (dec.)(lit.)
Molecular Formula C9H6ClNO2
Molecular Weight 195.602
Flash Point 225.8±23.2 °C
Exact Mass 195.008713
PSA 53.09000
LogP 3.09
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.728
Storage condition 0-6°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL5998400
CHEMICAL NAME :
1H-Indole-2-carboxylic acid, 5-chloro-
CAS REGISTRY NUMBER :
10517-21-2
BEILSTEIN REFERENCE NO. :
0153229
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H6-Cl-N-O2
MOLECULAR WEIGHT :
195.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,659,1972

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NL5998400
HS Code 29339990

 Synthetic Route

~90%

5-Chloroindole-2-carboxylic acid Structure

5-Chloroindole-...

CAS#:10517-21-2

Literature: Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157

~%

5-Chloroindole-2-carboxylic acid Structure

5-Chloroindole-...

CAS#:10517-21-2

Literature: European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 3149 - 3157

~%

5-Chloroindole-2-carboxylic acid Structure

5-Chloroindole-...

CAS#:10517-21-2

Literature: European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 3149 - 3157

~%

5-Chloroindole-2-carboxylic acid Structure

5-Chloroindole-...

CAS#:10517-21-2

Literature: Journal of the Chemical Society, , p. 3493,3494

~%

5-Chloroindole-2-carboxylic acid Structure

5-Chloroindole-...

CAS#:10517-21-2

Literature: Journal of the Chemical Society, , p. 3499,3502

~%

5-Chloroindole-2-carboxylic acid Structure

5-Chloroindole-...

CAS#:10517-21-2

Literature: Journal of the Chemical Society, , p. 3499,3502

~%

5-Chloroindole-2-carboxylic acid Structure

5-Chloroindole-...

CAS#:10517-21-2

Literature: European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 3149 - 3157

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles1

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The potency, specificity and reversibility of various presumed glycine site N-methyl-D-aspartate (NMDA) antagonists was studied on neonatal rat spinal cord using the grease gap technique. 5,7-Dichloro...

 Synonyms

1H-Indole-2-carboxylic acid, 5-chloro-
5-Chloro-1H-indole-2-carboxylic acid
5-Chloroindole-2-carboxylic acid
MFCD00005613
EINECS 234-050-1