JNJ-7777120
JNJ-7777120 structure
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Common Name | JNJ-7777120 | ||
|---|---|---|---|---|
| CAS Number | 459168-41-3 | Molecular Weight | 277.749 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 477.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C14H16ClN3O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 242.3±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of JNJ-7777120JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.IC50 value: 4 ±1 nM (Ki) [1] Target: histamine H4 receptorin vitro: JNJ-7777120 prevents fibronectin-induced lung fibroblast migration, thus suggesting that H4R could represent an attractive target for the development of new drugs for lung fibrosis treatment .[2]in vivo: JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. In addition, it can block the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model. [3] |
| Name | 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine |
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| Synonym | More Synonyms |
| Description | JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.IC50 value: 4 ±1 nM (Ki) [1] Target: histamine H4 receptorin vitro: JNJ-7777120 prevents fibronectin-induced lung fibroblast migration, thus suggesting that H4R could represent an attractive target for the development of new drugs for lung fibrosis treatment .[2]in vivo: JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. In addition, it can block the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model. [3] |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 477.0±45.0 °C at 760 mmHg |
| Molecular Formula | C14H16ClN3O |
| Molecular Weight | 277.749 |
| Flash Point | 242.3±28.7 °C |
| Exact Mass | 277.098175 |
| PSA | 39.34000 |
| LogP | 0.69 |
| Appearance of Characters | solid | white |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.656 |
| Storage condition | Store at +4°C |
| Water Solubility | H2O: insoluble |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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~81%
JNJ-7777120 CAS#:459168-41-3 |
| Literature: Lazewska, Dorota; Karolak-Wojciechowska, Janina; Kolesinska, Beata; Kaminski, Zbigniew; Kiec-Kononowicz, Katarzyna Heterocyclic Communications, 2011 , vol. 17, # 5-6 p. 207 - 210 |
| Precursor 2 | |
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| DownStream 0 | |
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Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction.
Microcirculation 22 , 237-48, (2015) The mechanisms by which histamine increases microvascular permeability remain poorly understood. We tested the hypothesis that H1 receptor activation disrupts the endothelial barrier and investigated ... |
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Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration.
Br. J. Pharmacol. 171(15) , 3754-63, (2014) The present treatment for choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) is not sufficient. Hence, we examined the therapeutic efficacy of reducing histamine... |
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Analysis of the histamine H2-receptor in human monocytes.
Biochem. Pharmacol. 92(2) , 369-79, (2014) Histamine receptors are G-protein-coupled receptors (GPCRs). Canonically, the histamine H2-receptor (H2R) couples to Gs-proteins and activates adenylyl cyclases (ACs) with subsequent adenosine-3',5'-c... |
| Methanone, (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)- |
| (5-Chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)methanone |
| JNJ-7777120 |
| (5-chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone |
| (5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone |
| 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine |