Z164597606
Modify Date: 2023-03-02 10:04:19
Z164597606 structure
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Common Name | Z164597606 | ||
|---|---|---|---|---|
| CAS Number | 1050587-57-9 | Molecular Weight | 365.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H19N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Z164597606Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE). Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD)[1][2]. |
| Name | Z164597606 |
|---|
| Description | Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE). Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD)[1][2]. |
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| Related Catalog | |
| Target |
eqBCHE:1.3 μM (IC50) hBCHE:1.7 μM (IC50) |
| In Vitro | Z164597606 (10 μM) potently inhibits BChE activity, with no more than 30% inhibitory against ACHE[1]. Z164597606 (0.5-20 μM) may bind to catalytic “anionic” site (CAS) when interacting with BChE (determined by Lineweaver-Burk reciprocal plots)[1]. Z164597606 (10 and 50 μM) shows no toxicity on neuronal cell line SH-SY5Y[1]. |
| References |
| Molecular Formula | C20H19N3O4 |
|---|---|
| Molecular Weight | 365.38 |