1050587-57-9

1050587-57-9 structure

Name: Z164597606
Chemical Name: Z164597606
CAS Number: 1050587-57-9
Molecular Formula: C₂₀H₁₉N₃O₄
Molecular Weight: 365.38
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-10-10 18:42:06
Modify Date: 2023-03-02 10:04:19
Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE). Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD)[1][2].

Name	Z164597606

Description	Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE). Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD)[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	eqBCHE:1.3 μM (IC50) hBCHE:1.7 μM (IC50)
In Vitro	Z164597606 (10 μM) potently inhibits BChE activity, with no more than 30% inhibitory against ACHE[1]. Z164597606 (0.5-20 μM) may bind to catalytic “anionic” site (CAS) when interacting with BChE (determined by Lineweaver-Burk reciprocal plots)[1]. Z164597606 (10 and 50 μM) shows no toxicity on neuronal cell line SH-SY5Y[1].
References	[1]. Xin Lu, et al. Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation. Bioorg Chem. 2019 Apr;85:117-127. [2]. Xin Lu, et al. Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Sep 2;243:114729.

Molecular Formula	C₂₀H₁₉N₃O₄
Molecular Weight	365.38