CP-67804

Modify Date: 2024-01-08 16:30:48

CP-67804 Structure
CP-67804 structure
Common Name CP-67804
CAS Number 103978-08-1 Molecular Weight 345.29700
Density 1.456g/cm3 Boiling Point 526.5ºC at 760 mmHg
Molecular Formula C18H13F2NO4 Melting Point N/A
MSDS N/A Flash Point 272.2ºC

 Use of CP-67804


CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent[1].

 Names

Name 1-ethyl-6,8-difluoro-7-(4-hydroxyphenyl)-4-oxoquinoline-3-carboxylic acid
Synonym More Synonyms

 CP-67804 Biological Activity

Description CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent[1].
Related Catalog
Target

Topoisomerase II

In Vitro CP-67804 increases topoisomerase II-mediated DNA breakages by enhancing the enzyme's forward rate of cleavage[1].
References

[1]. Robinson MJ, et al. Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage. J Biol Chem. 1991;266(22):14585-14592.

 Chemical & Physical Properties

Density 1.456g/cm3
Boiling Point 526.5ºC at 760 mmHg
Molecular Formula C18H13F2NO4
Molecular Weight 345.29700
Flash Point 272.2ºC
Exact Mass 345.08100
PSA 79.53000
LogP 3.37040
Vapour Pressure 6.52E-12mmHg at 25°C
Index of Refraction 1.623

 Synonyms

3-Quinolinecarboxylic acid,1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxyphenyl)-4-oxo
1-Ethyl-6,8-difluoro-7-(4-hydroxyphenyl)-4-quinolone-3-carboxylic acid
CP-67,804