MK-4074 sodium salt
Modify Date: 2025-09-21 08:54:28
MK-4074 sodium salt structure
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Common Name | MK-4074 sodium salt | ||
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| CAS Number | 1039758-18-3 | Molecular Weight | 587.608 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H30N3NaO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK-4074 sodium saltMK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver. Steatohepatitis Phase 1 Clinical |
| Name | MK-4074 sodium salt |
|---|
| Description | MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver. Steatohepatitis Phase 1 Clinical |
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| References | References 1. Kim CW, et al. Cell Metab. 2017 Aug 1;26(2):394-406.e6. View Related Products by Target Acetyl-CoA Carboxylase (ACC) Steatohepatitis |
| Molecular Formula | C33H30N3NaO6 |
|---|---|
| Molecular Weight | 587.608 |
| InChIKey | GGRZUOUSTJCEBC-UHFFFAOYSA-M |
| SMILES | COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4cncc(C(=O)[O-])c4)ccc2O3)cc2c1c(C)cn2C1CC1.[Na+] |