1039758-18-3
1039758-18-3 structure
- Name: MK-4074 sodium salt
- Chemical Name: MK-4074 sodium salt
- CAS Number: 1039758-18-3
- Molecular Formula: C33H30N3NaO6
- Molecular Weight: 587.608
- Create Date: 2020-01-11 19:02:02
- Modify Date: 2024-02-04 18:26:45
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MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver. Steatohepatitis Phase 1 Clinical
| Name | MK-4074 sodium salt |
|---|
| Description | MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver. Steatohepatitis Phase 1 Clinical |
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| References | References 1. Kim CW, et al. Cell Metab. 2017 Aug 1;26(2):394-406.e6. View Related Products by Target Acetyl-CoA Carboxylase (ACC) Steatohepatitis |
| Molecular Formula | C33H30N3NaO6 |
|---|---|
| Molecular Weight | 587.608 |