6-Maleimidocaproic acid sulfo-NHS

Modify Date: 2024-01-02 12:40:18

6-Maleimidocaproic acid sulfo-NHS Structure
6-Maleimidocaproic acid sulfo-NHS structure
Common Name 6-Maleimidocaproic acid sulfo-NHS
CAS Number 103848-61-9 Molecular Weight 388.35000
Density N/A Boiling Point N/A
Molecular Formula C14H16N2O9S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 6-Maleimidocaproic acid sulfo-NHS


6-Maleimidocaproic acid sulfo-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-[6-(2,5-dioxopyrrol-1-yl)hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
Synonym More Synonyms

 6-Maleimidocaproic acid sulfo-NHS Biological Activity

Description 6-Maleimidocaproic acid sulfo-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C14H16N2O9S
Molecular Weight 388.35000
Exact Mass 388.05800
PSA 163.81000

 Synonyms

1H-Pyrrole-1-hexanoicacid,2,5-dihydro-2,5-dioxo-,2,5-dioxo-3-sulfo-1-pyrrolidinyl ester
BICL221
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