6-Maleimidocaproic acid sulfo-NHS

Modify Date: 2024-01-02 12:40:18

6-Maleimidocaproic acid sulfo-NHS structure	Common Name	6-Maleimidocaproic acid sulfo-NHS
	CAS Number	103848-61-9	Molecular Weight	388.35000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₆N₂O₉S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 6-Maleimidocaproic acid sulfo-NHS

6-Maleimidocaproic acid sulfo-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-[6-(2,5-dioxopyrrol-1-yl)hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
Synonym	More Synonyms

Description	6-Maleimidocaproic acid sulfo-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

1H-Pyrrole-1-hexanoicacid,2,5-dihydro-2,5-dioxo-,2,5-dioxo-3-sulfo-1-pyrrolidinyl ester

BICL221

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